THE ENDOCANNABINOID SYSTEM: PHYSIOLOGY AND PHARMACOLOGY
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چکیده
منابع مشابه
The endocannabinoid system: physiology and pharmacology.
The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared early in evolution and which has important regulatory functions throughout the body in all vertebrates. The main endocannabinoids (endogenous cannabis-like substances) are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol. They bind to a family o...
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Introduction Although the endocannabinoid system (ECS) is best known for its important neuromodulatory role, it has become apparent in recent years that the physiology of almost every organ is affected by the ECS. This is especially true under pathological conditions, in which an up-regulation of the expression of cannabinoid receptors and increased endocannabinoid production can often be obser...
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This chapter will review the basic pharmacology of endocannabinoid receptors. As the best-described cannabinoid receptors are G-protein-coupled receptors (GPCRs), those will be the focus of this chapter. We will start with a basic review of GPCR signaling, as these concepts are critical to understanding the function of cannabinoid receptors. Next, several features of cannabinoid receptor signal...
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ژورنال
عنوان ژورنال: Alcohol and Alcoholism
سال: 2004
ISSN: 1464-3502,0735-0414
DOI: 10.1093/alcalc/agh110